Open AccessAnesthetic Preconditioning Inhibits Isoflurane-Mediated Apoptosis in the Developing Rat Brain
Author(s) -
Jun Peng,
Julie K. Drobish,
Liang Ge,
Zhen Wu,
Chunxia Liu,
Donald J. Joseph,
Hossam Abdou,
Maryellen F. Eckenhoff,
Huafeng Wei
Publication year - 2014
Publication title -
anesthesia and analgesia/anesthesia and analgesia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.404
H-Index - 201
eISSN - 1526-7598
pISSN - 0003-2999
DOI - 10.1213/ane.0000000000000380
Subject(s) - isoflurane , medicine , anesthetic , anesthesia , apoptosis , hippocampus , neurodegeneration , caspase 3 , western blot , pharmacology , programmed cell death , biology , biochemistry , disease , gene
We hypothesized that preconditioning (PC) with a short exposure to isoflurane (ISO) would reduce neurodegeneration induced by prolonged exposure to ISO in neonatal rats, as previously shown in neuronal cell culture.