Open AccessThe Role of Hippocampal Tau Protein Phosphorylation in Isoflurane-Induced Cognitive Dysfunction in Transgenic APP695 Mice
Author(s) -
Changsheng Li,
Sufang Liu,
Ying Xing,
Feng Tao
Publication year - 2014
Publication title -
anesthesia and analgesia/anesthesia and analgesia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.404
H-Index - 201
eISSN - 1526-7598
pISSN - 0003-2999
DOI - 10.1213/ane.0000000000000315
Subject(s) - morris water navigation task , isoflurane , hippocampal formation , medicine , genetically modified mouse , hippocampus , anesthesia , endocrinology , transgene , tau protein , alzheimer's disease , biology , disease , biochemistry , gene
Previous studies have shown that exposure to inhaled anesthetics can cause cognitive dysfunction, suggesting that general anesthesia might be a risk factor for the development of Alzheimer disease. However, the underlying mechanisms remain to be elucidated. In the present study, we tested our hypothesis that enhanced tau protein phosphorylation in hippocampus contributes to isoflurane-induced cognitive dysfunction in a mouse model of Alzheimer disease.