Open AccessHIV-associated neurologic disease incidence changes:
Author(s) -
Ned Sacktor,
Robert H. Lyles,
Richard L. Skolasky,
Cynthia A. Kleeberger,
Ola A. Selnes,
Eric N. Miller,
James T. Becker,
Bruce A. Cohen,
Justin C. McArthur
Publication year - 2001
Publication title -
neurology
Language(s) - Uncategorized
Resource type - Journals
SCImago Journal Rank - 2.91
H-Index - 364
eISSN - 1526-632X
pISSN - 0028-3878
DOI - 10.1212/wnl.56.2.257
Subject(s) - medicine , incidence (geometry) , progressive multifocal leukoencephalopathy , dementia , multicenter aids cohort study , pediatrics , toxoplasmosis , meningitis , antiretroviral therapy , cohort , human immunodeficiency virus (hiv) , disease , immunology , viral load , multiple sclerosis , physics , optics
This study examined the temporal trends in the incidence rates of HIV dementia, cryptococcal meningitis, toxoplasmosis, progressive multifocal leukoencephalopathy, and CNS lymphoma from January 1990 to December 1998 in the Multicenter AIDS Cohort Study. The incidence rates for HIV dementia, cryptococcal meningitis, and lymphoma decreased following the introduction of highly active antiretroviral therapy (HAART). The proportion of new cases of HIV dementia with a CD4 count in a higher range (i.e., 201 to 350) since 1996 may be increasing.