Open AccessDetermination of language dominance using functional MRI
Author(s) -
Jeffrey R. Binder,
Sara J. Swanson,
Thomas A. Hammeke,
George L. Morris,
Wade M. Mueller,
M. Fischer,
Selim R. Benbadis,
J.A. Frost,
Stephen M. Rao,
Victor M. Haughton
Publication year - 1996
Publication title -
neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.91
H-Index - 364
eISSN - 1526-632X
pISSN - 0028-3878
DOI - 10.1212/wnl.46.4.978
Subject(s) - cognition , psychology , argument (complex analysis) , dominance (genetics) , informed consent , clinical trial , social cognition , psychotherapist , medicine , neuroscience , alternative medicine , pathology , biochemistry , gene , chemistry
We performed functional MRI (FMRI) in 22 consecutive epilepsy patients undergoing intracarotid amobarbital (Wada) testing and compared language lateralization measures obtained with the two procedures. FMRI used a single-word semantic decision task previously shown to activate lateralized language areas in normal adults. Correlation between the two tests was highly significant (r = 0.96; 95% CIs 0.90 to 0.98; p < 0.0001). These results validate the FMRI technique and suggest that "active" areas observed with this semantic processing task correspond to those underlying hemispheric dominance for language. This strong correlation observed supports the view that language lateralization is a continuous rather than a dichotomous variable. In addition to lateralization information, FMRI consistently demonstrated focal regions of activity in lateral frontal and temporo-parieto-occipital cortex. These functional maps may be helpful in defining the boundaries of surgical excisions.
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