Open AccessNeuronal antinuclear antibody in sensory neuronopathy from lung cancer
Author(s) -
Francesc Graus,
Carlos CordonCardo,
Jerome B. Posner
Publication year - 1985
Publication title -
neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.91
H-Index - 364
eISSN - 1526-632X
pISSN - 0028-3878
DOI - 10.1212/wnl.35.4.538
Subject(s) - immunoperoxidase , pathology , anti nuclear antibody , staining , antibody , immunofluorescence , immunocytochemistry , cytoplasm , lung cancer , lung , biology , immunohistochemistry , medicine , monoclonal antibody , autoantibody , immunology , microbiology and biotechnology
We found an antinuclear antibody highly restricted to nuclei of neurons in two patients with subacute sensory neuronopathy complicating oat cell carcinoma of the lung. Serum was tested by indirect immunofluorescence and immunoperoxidase staining. At low concentrations of antibody, only the nuclei of the neurons were stained. At high concentrations, there was also staining of the nuclei of glial cells and fetal nonneural tissues. The cytoplasm of most neurons was stained with the immunoperoxidase method.
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