Stress-induced cardiac insufficiency relating to abnormal leptin and FKBP12.6 is ameliorated by CPU0213, an endothelin receptor antagonist, which is not affected by the CYP3A suppressing effect of erythromycin | Zendy

Yusi Cheng | Zendy; Yin Dai | Zendy; DeZai Dai | Zendy

Open Access

Stress-induced cardiac insufficiency relating to abnormal leptin and FKBP12.6 is ameliorated by CPU0213, an endothelin receptor antagonist, which is not affected by the CYP3A suppressing effect of erythromycin

Author(s) -

Yusi Cheng,

Yin Dai,

DeZai Dai

Publication year - 2009

Publication title -

journal of pharmacy and pharmacology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.745

H-Index - 118

eISSN - 2042-7158

pISSN - 0022-3573

DOI - 10.1211/jpp/61.05.0004

Subject(s) - endothelin receptor antagonist , erythromycin , medicine , antagonist , endothelin receptor , receptor antagonist , endothelin 1 , leptin , pharmacology , receptor , biology , antibiotics , microbiology and biotechnology , obesity

Cardiac injury induced by isoprenaline produces stress. This stress can be mediated by the activated endothelin and leptin pathway; thus, the endothelin receptor antagonist CPU0213 may reverse these changes. CPU0213 is metabolized mainly by cytochrome P450 (CYP)3A, thus, erythromycin, an inhibitor of CYP3A, could affect its effects by raising its plasma levels.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research