Open AccessNovel mucoadhesive nasal inserts based on chitosan/hyaluronate polyelectrolyte complexes for peptide and protein delivery
Author(s) -
Luppi Barbara,
Bigucci Federica,
Mercolini Laura,
Musenga Alessandro,
Sorrenti Milena,
Catenacci Laura,
Zecchi Vittorio
Publication year - 2009
Publication title -
journal of pharmacy and pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.745
H-Index - 118
eISSN - 2042-7158
pISSN - 0022-3573
DOI - 10.1211/jpp.61.02.0003
Subject(s) - mucoadhesion , chitosan , polyelectrolyte , swelling , nasal administration , chemistry , thermogravimetric analysis , polymer chemistry , drug delivery , chromatography , materials science , biomedical engineering , nuclear chemistry , polymer , pharmacology , drug carrier , biochemistry , organic chemistry , medicine , composite material
Objectives The purpose of this study was the preparation and characterisation of mucoadhesive nasal inserts based on chitosan/hyaluronate polyelectrolyte complexes prepared at various pHs and at different molar ratios. Methods A suspension of chitosan/hyaluronate complexes with or without the model drugs (vancomycin or insulin) was lyophilised into small inserts. Complexation yield, FT‐IR spectra and thermogravimetric analysis were used to study the degree of interactive strength between polyions. In‐vitro swelling, mucoadhesion and release tests were performed in order to investigate delivery of vancomycin and insulin in the nasal cavity. Key findings The results indicated that the selection of complex preparative conditions allows modulation of insert swelling and mucoadhesion ability. Nasal inserts containing vancomycin or insulin had showed completely different drug release behaviour. Conclusions Chitosan/hyaluronate polyelectrolyte complexes can be used for the formulation of mucoadhesive nasal inserts for the delivery of peptide and protein drugs.