Open AccessAntinociceptive and anti‐inflammatory effects of the essential oil from Eremanthus erythropappus leaves
Author(s) -
Sousa Orlando V.,
Silvério Marcelo S.,
DelVechioVieira Glauciemar,
Matheus Filipe C.,
Yamamoto Célia H.,
Alves Maria S.
Publication year - 2008
Publication title -
journal of pharmacy and pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.745
H-Index - 118
eISSN - 2042-7158
pISSN - 0022-3573
DOI - 10.1211/jpp.60.6.0013
Subject(s) - licking , carrageenan , chemistry , essential oil , traditional medicine , analgesic , nociception , pharmacology , ed50 , myrcene , medicine , food science , biochemistry , limonene , in vitro , receptor
The chemical composition of the essential oil from air‐dried leaves of Eremanthus erythropappus was studied. The main compounds were β‐pinene (23.24%), β‐caryophyllene (22.92%), β‐myrcene (10.03%) and germacrene D (9.40%). The essential oil had an LD50 of 2.90 gkg −1 in mice. Doses of 200 and 400 mgkg −1 inhibited 10.69% and 27.06% of acetic‐acid‐induced writhing in mice, respectively. In the formalin‐induced nociception test in mice, the essential oil inhibited the first phase of paw licking by 29.13% (400 mgkg −1 ) and the second phase by 32.74% (200 mgkg −1 ) and 37.55% (400 mgkg −1 ). In the hot‐plate test in mice, doses of 200 mgkg −1 and 400 mgkg −1 significantly increased the reaction time after 30, 60 and 90 min of treatment. Doses of 200 and 400 mgkg −1 inhibited carrageenan‐induced paw oedema in rats by 15.18% and 36.61%, respectively. Doses of 200 and 400 mgkg −1 administered 4 h before intra‐pleural injection of carrageenan significantly reduced exudate volume (by 20.20% and 48.70%, respectively) and leucocyte mobilization (by 5.88% and 17.29%, respectively). These results demonstrate that E. erythropappus has analgesic and anti‐inflammatory properties, supporting the use of this plant in folk medicine.