Open AccessThe anti‐inflammatory modulatory role of Solidago chilensis Meyen in the murine model of the air pouch
Author(s) -
Liz Rafael,
Vigil Silvana Virginia Gagliotti,
Goulart Stella,
Izabel Maria,
Moritz Goularte,
Schenkel Eloir Paulo,
Fröde Tânia Silvia
Publication year - 2008
Publication title -
journal of pharmacy and pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.745
H-Index - 118
eISSN - 2042-7158
pISSN - 0022-3573
DOI - 10.1211/jpp.60.4.0015
Subject(s) - rhizome , chemistry , carrageenan , pharmacology , anti inflammatory , in vivo , dexamethasone , nitric oxide , inflammation , traditional medicine , biochemistry , biology , medicine , immunology , endocrinology , microbiology and biotechnology , organic chemistry
The aim of this study was to investigate the anti‐inflammatory efficacy of an aqueous extract (AE), and its butanolic (BuOH) and aqueous residual (AR) fractions, derived from the rhizome of Solidago chilensis in inflammation caused by carrageenan in mice. Solidago chilensis Meyen rhizome was extracted using hot water at 90°C under infusion. The extract was filtered and lyophilized. Part of the aqueous extract was fractionated with n‐BuOH, resulting in butanolic (BuOH) and aqueous residual (AR) fractions. Adult Swiss mice were used in the in‐vivo experiments. We evaluated the effect of rhizome aqueous extract of Solidago chilensis and these two derived fractions on the inflammation induced by carrageenan in the mouse model of the air pouch. The aqueous extract and its derived fractions significantly inhibited leucocytes, neutrophils, exudation, myeloperoxidase and adenosine deaminase activity, as well as nitric oxide, interleukin‐1 beta (IL‐1β), neutrophil chemokine (KC) and tumour necrosis factor‐alpha (TNF‐α) levels ( P < 0.05). Indometacin and dexamethasone inhibited all the studied inflammatory parameters ( P < 0.01) with the exceptions that indometacin did not inhibit TNF‐α levels and dexamethasone did not inhibit KC levels ( P > 0.05). These results indicate that Solidago chilensis has a significant anti‐inflammatory action on acute inflammatory responses and that its inhibitory activity may be due not only to the inhibition of pro‐inflammatory mediators, but also to the inhibition of leucocyte infiltration.