Open AccessThe future of open‐ and closed‐loop insulin delivery systems
Author(s) -
Farmer Terry G.,
Edgar Thomas F.,
Peppas Nicholas A.
Publication year - 2008
Publication title -
journal of pharmacy and pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.745
H-Index - 118
eISSN - 2042-7158
pISSN - 0022-3573
DOI - 10.1211/jpp.60.1.0001
Subject(s) - diabetes mellitus , insulin , closed loop , insulin delivery , metabolic control analysis , glucose homeostasis , hormone , computer science , medicine , control (management) , control system , endocrinology , insulin resistance , type 1 diabetes , control engineering , engineering , artificial intelligence , electrical engineering
We have analysed several aspects of insulin‐dependent diabetes mellitus, including the glucose metabolic system, diabetes complications, and previous and ongoing research aimed at controlling glucose in diabetic patients. An expert review of various models and control algorithms developed for the glucose homeostasis system is presented, along with an analysis of research towards the development of a polymeric insulin infusion system. Recommendations for future directions in creating a true closed‐loop glucose control system are presented, including the development of multivariable models and control systems to more accurately describe and control the multi‐metabolite, multi‐hormonal system, as well as in‐vivo assessments of implicit closed‐loop control systems.