Open AccessInfluence of single versus multiple actuations on the particle size distribution of beclometasone dipropionate metered‐dose inhalers
Author(s) -
Feddah M. R.,
Davies N. M.
Publication year - 2003
Publication title -
journal of pharmacy and pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.745
H-Index - 118
eISSN - 2042-7158
pISSN - 0022-3573
DOI - 10.1211/0022357021549
Subject(s) - beclometasone dipropionate , cascade impactor , aerosol , particle size , particle (ecology) , impaction , aerodynamic diameter , chemistry , medicine , surgery , lung , organic chemistry , respiratory disease , oceanography , geology
The particle size distributions of beclometasone dipropionate delivered from Becotide and Respocort inhalers after single and multiple actuations were investigated using the Andersen Mark II Cascade impactor and the drug was quantified using high performance liquid chromatography. The fine particle mass and the mass median aerodynamic diameter were calculated. An apparent increase in mass median aerodynamic diameter was observed when the number of actuations increased. In addition, the fine particle mass decreased as the number of actuations increased. When performing and analysing cascade impaction study data differences between single versus multiple actuations must be considered. Regulatory guidelines should be amended to stipulate the number of actuations to be loaded into devices used to evaluate the particle size distribution of inhaled aerosol products.