Open AccessEffects of absorption rate on the pre‐systemic chiral inversion of ibuprofen in rabbits
Author(s) -
Doki Kosuke,
Hayakawa Toru,
Lin Wenhui,
Yanaguimoto Hitomi,
Ding Guohua,
Inotsume Nobuo
Publication year - 2003
Publication title -
journal of pharmacy and pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.745
H-Index - 118
eISSN - 2042-7158
pISSN - 0022-3573
DOI - 10.1211/0022357021404
Subject(s) - ibuprofen , enantiomer , oral administration , chemistry , pharmacology , absorption rate , absorption (acoustics) , route of administration , chromatography , anesthesia , medicine , stereochemistry , materials science , composite material
The chiral inversion kinetics of ibuprofen was evaluated after intraduodenal administration of racemic ibuprofen in conventional powder form and sustained‐released granules compared with intravenous administration in rabbits. The AUC ratios of the S ‐(+) and R ‐(–) enantiomers remained almost constant values with time up to 2 h after administration of sustained‐release formulation, while those after administration of the powder increased with time. R ‐(–) enantiomer to S ‐(–) enantiomer inversion ratios after intraduodenal administration of the powder form and the sustained‐release form, and after intravenous injection were calculated to be 1.63, 1.94 and 1.19, respectively, indicating that pharmacological effects may depend on the absorption rate in rabbits.