Open AccessArachidonic acid and its metabolites are involved in the expression of neocortical spike‐and‐wave spindling episodes in DBA/2J mice
Author(s) -
Capasso A.,
Loizzo A.,
Capasso A.
Publication year - 2001
Publication title -
journal of pharmacy and pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.745
H-Index - 118
eISSN - 2042-7158
pISSN - 0022-3573
DOI - 10.1211/0022357011776045
Subject(s) - dexamethasone , indometacin , mifepristone , endocrinology , medicine , glucocorticoid , antagonist , arachidonic acid , antiglucocorticoid , pharmacology , chemistry , spike and wave , glucocorticoid receptor , receptor , biology , epilepsy , cyclooxygenase , biochemistry , pregnancy , enzyme , prostaglandin endoperoxide synthase , psychiatry , genetics
This work was undertaken to study the effects of dexamethasone, indometacin and mifepristone plus dexamethasone on the neocortical spike‐and‐wave spindling episodes (S&W) in the electrocorticogram of DBA/2J mice. Our data indicate that both dexamethasone and indometacin (1, 10, 100 μg kg −1 , i.p.) reduced the S&W of DBA/2J mice. This effect appeared 30 min after drug administration and lasted for the duration of the recording period (240 min). Mifepristone, a glucocorticoid receptor antagonist (1, 10, 100 μg kg −1 , i.p.), injected 2 h before dexamethasone, totally blocked the steroid effect. These results indicate that both dexamethasone and indometacin significantly reduce the S&W of DBA/2J mice, suggesting a possible involvement of arachidonic acid and its metabolites in the development of brain excitability.