Functional isoforms of Pit-1 generated by alternative messenger RNA splicing. | Zendy

K. E. Konzak | Zendy; David D. Moore | Zendy

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Functional isoforms of Pit-1 generated by alternative messenger RNA splicing.

Author(s) -

K. E. Konzak,

David D. Moore

Publication year - 1992

Publication title -

molecular endocrinology

Language(s) - English

Resource type - Journals

eISSN - 1944-9917

pISSN - 0888-8809

DOI - 10.1210/mend.6.2.1569967

Subject(s) - biology , gene isoform , alternative splicing , transactivation , rna splicing , intron , microbiology and biotechnology , messenger rna , complementary dna , splicing factor , promoter , exon , minigene , splice , transcription (linguistics) , gene , gene expression , rna , genetics , linguistics , philosophy

Pit-1 is a pituitary-specific transcription factor that activates expression of the GH and PRL genes. We have isolated a cDNA encoding a variant isoform of Pit-1 that we term Pit-1 beta. Pit-1 beta contains an insertion of 26 amino acids in the transactivation domain as a consequence of the utilization of an alternative 3' splice acceptor at the end of the first intron. Like the previously described Pit-1 alpha, Pit-1 beta transactivates both the GH and PRL promoters. However, the larger isoform acts as a more potent inducer of GH.

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