The Synergistic Activity of Thyroid Transcription Factor 1 and Pax 8 Relies on the Promoter/Enhancer Interplay | Zendy

Stefania Miccadei | Zendy; Rossana De Leo | Zendy; Enrico Zammarchi | Zendy; Pier Giorgio Natali | Zendy; Donato Civitareale | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

The Synergistic Activity of Thyroid Transcription Factor 1 and Pax 8 Relies on the Promoter/Enhancer Interplay

Author(s) -

Stefania Miccadei,

Rossana De Leo,

Enrico Zammarchi,

Pier Giorgio Natali,

Donato Civitareale

Publication year - 2002

Publication title -

molecular endocrinology

Language(s) - English

Resource type - Journals

eISSN - 1944-9917

pISSN - 0888-8809

DOI - 10.1210/mend.16.4.0808

Subject(s) - enhancer , biology , transcription factor , thyroid transcription factor 1 , thyroglobulin , thyroid , enhancer rnas , gene , promoter , microbiology and biotechnology , transcription (linguistics) , gene expression , regulation of gene expression , genetics , linguistics , philosophy

The transcription factors, thyroid transcription factor 1 (TTF-1) and Pax 8, play a pivotal role in the transcriptional regulation of the thyroid differentiation marker genes and in the differentiation of the thyroid follicular cells. They have a very restricted tissue distribution, and the thyrocyte is the only cell type with the simultaneous expression of these factors. Here we show that TTF-1 and Pax 8 cooperatively activate their target genes and that their synergistic activity requires the cross-talk between enhancer and gene promoter. We have characterized the cis and trans requirements of the TTF1/Pax 8 synergistic activity on the thyroperoxidase gene. We show that their synergy is also important for thyroglobulin gene transcription.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research