Puromycin-Sensitive Aminopeptidase Is Essential for the Maternal Recognition of Pregnancy in Mice | Zendy

Tomoharu Osada | Zendy; Gen Watanabe | Zendy; Yoshiyuki Sakaki | Zendy; Takashi Takeuchi | Zendy

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Puromycin-Sensitive Aminopeptidase Is Essential for the Maternal Recognition of Pregnancy in Mice

Author(s) -

Tomoharu Osada,

Gen Watanabe,

Yoshiyuki Sakaki,

Takashi Takeuchi

Publication year - 2001

Publication title -

molecular endocrinology

Language(s) - English

Resource type - Journals

eISSN - 1944-9917

pISSN - 0888-8809

DOI - 10.1210/mend.15.6.0644

Subject(s) - biology , puromycin , pregnancy , corpus luteum , secretion , gestation , endocrinology , transplantation , medicine , aminopeptidase , infertility , prolactin , andrology , hormone , leucine , protein biosynthesis , microbiology and biotechnology , biochemistry , genetics , amino acid

Maternal recognition of pregnancy in rodents requires semicircadian surges of hypophyseal PRL secretion during early gestation, which are required for the formation of the corpus luteum of pregnancy (CLP). Here we show that puromycin-sensitive aminopeptidase (Psa)-deficient mice display female infertility that results from impaired formation of CLP. Transplantation of mutant ovaries into normal females restored fertility but not vice versa. Psa-deficient females revealed no semicircadian surges of PRL induced after mating stimuli. Pregnancy in the mutant females was restored by grafting intact pituitaries to elevate circulating levels of PRL. Psa is thus required for the appearance of the semicircadian surges of PRL secretion that are crucial for maintaining pregnancy in rodents.

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