Expression of Adrenocorticotropin-Releasing Hormone Precursor Gene in Placenta and Other Nonhypothalamic Tissues in Man | Zendy

Takeshi Usui | Zendy; Yoshikatsu Nakai | Zendy; Toshihiko Tsukada | Zendy; Hisato Jingami | Zendy; Hideo Takahashi | Zendy; Junichi Fukata | Zendy; Hiroo Imura | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Expression of Adrenocorticotropin-Releasing Hormone Precursor Gene in Placenta and Other Nonhypothalamic Tissues in Man

Author(s) -

Takeshi Usui,

Yoshikatsu Nakai,

Toshihiko Tsukada,

Hisato Jingami,

Hideo Takahashi,

Junichi Fukata,

Hiroo Imura

Publication year - 1988

Publication title -

molecular endocrinology

Language(s) - English

Resource type - Journals

eISSN - 1944-9917

pISSN - 0888-8809

DOI - 10.1210/mend-2-9-871

Subject(s) - biology , hypothalamus , placenta , endocrinology , medicine , northern blot , messenger rna , gene expression , hormone , pituitary gland , gene , fetus , pregnancy , biochemistry , genetics

Adrenocorticotropin-releasing hormone (CRH) is a peptide originally isolated from the hypothalamus. Immunocytochemical and RIA studies have revealed that CRH-like peptide is also localized in human nonhypothalamic tissues and some tumors. To see if CRH is synthesized in these nonhypothalamic tissues and tumors, we examined preproCRH mRNA in these tissues by Northern blot analysis using a cloned human preproCRH gene as a probe. PreproCRH mRNA was detected in human hypothalamus, cerebral cortex, adrenal gland, placenta, pheochromocytoma, and thymic carcinoid. The content of preproCRH mRNA in placenta was apparently greater than that in the whole hypothalamus.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research