Minireview: Steroid/Nuclear Receptor-Regulated Dynamics of Occluding and Anchoring Junctions | Zendy

Gary L. Firestone | Zendy; Bhumika J. Kapadia | Zendy

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Minireview: Steroid/Nuclear Receptor-Regulated Dynamics of Occluding and Anchoring Junctions

Author(s) -

Gary L. Firestone,

Bhumika J. Kapadia

Publication year - 2014

Publication title -

molecular endocrinology

Language(s) - English

Resource type - Journals

eISSN - 1944-9917

pISSN - 0888-8809

DOI - 10.1210/me.2014-1037

Subject(s) - adherens junction , biology , microbiology and biotechnology , septate junctions , transmembrane protein , cell junction , nuclear receptor , signal transduction , receptor , cytoplasm , intracellular , biophysics , cadherin , gap junction , transcription factor , cell , genetics , gene

A diverse set of physiological signals control intercellular interactions by regulating the structure and function of occluding junctions (tight junctions) and anchoring junctions (adherens junctions and desmosomes). These plasma membrane junctions are comprised of multiprotein complexes of transmembrane and cytoplasmic peripheral plasma membrane proteins. Evidence from many hormone-responsive tissues has shown that expression, modification, molecular interactions, stability, and localization of junctional complex-associated proteins can be targeted by nuclear hormone receptors and their ligands through transcriptional and nontranscriptional mechanisms. The focus of this minireview is to discuss molecular, cellular, and physiological studies that directly link nuclear receptor- and ligand-triggered signaling pathways to the regulation of occluding and anchoring junction dynamics.

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