Minireview: Obesity and Breast Cancer: A Tale of Inflammation and Dysregulated Metabolism | Zendy

Evan R. Simpson | Zendy; Kristy A. Brown | Zendy

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Minireview: Obesity and Breast Cancer: A Tale of Inflammation and Dysregulated Metabolism

Author(s) -

Evan R. Simpson,

Kristy A. Brown

Publication year - 2013

Publication title -

molecular endocrinology

Language(s) - English

Resource type - Journals

eISSN - 1944-9917

pISSN - 0888-8809

DOI - 10.1210/me.2013-1011

Subject(s) - breast cancer , obesity , estrogen , biology , carcinogenesis , cancer , medicine , endometrial cancer , inflammation , metabolic syndrome , colorectal cancer , bioinformatics , cancer research , oncology , endocrinology

In addition to the spectrum of conditions known collectively as the Metabolic Syndrome, obesity is now recognized to be associated with increased risk of several cancers including colon, endometrial, and breast cancer. Obesity and carcinogenesis share 2 characteristics in common. On the one hand, they involve inflammatory pathways, and on the other hand, they involve dysregulated metabolism. In this review we focus on postmenopausal breast cancer and discuss the metabolic and cellular mechanisms whereby obesity and breast cancer are related. Because a majority of postmenopausal breast tumors are estrogen responsive, we include a discussion of the action of obesity-related factors on estrogen formation within the breast.

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