The Macrophage Migration Inhibitory Factor-Glucocorticoid Dyad: Regulation of Inflammation and Immunity | Zendy

Harry V. Flaster | Zendy; Jürgen Bernhagen | Zendy; Thierry Calandra | Zendy; Richard Bucala | Zendy

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The Macrophage Migration Inhibitory Factor-Glucocorticoid Dyad: Regulation of Inflammation and Immunity

Author(s) -

Harry V. Flaster,

Jürgen Bernhagen,

Thierry Calandra,

Richard Bucala

Publication year - 2007

Publication title -

molecular endocrinology

Language(s) - English

Resource type - Journals

eISSN - 1944-9917

pISSN - 0888-8809

DOI - 10.1210/me.2007-0065

Subject(s) - macrophage migration inhibitory factor , glucocorticoid , biology , inflammation , immunology , immune system , cytokine , macrophage , glucocorticoid receptor , immunopathology , immunity , dyad , mediator , endocrinology , psychology , social psychology , biochemistry , in vitro

The cytokine macrophage migration inhibitory factor (MIF) occupies a unique position in physiology by its ability to directly regulate the immunosuppressive actions of glucocorticoids. We review herein the interactions between MIF and glucocorticoids within the immune system and discuss the relevance of the MIF-glucocorticoid regulatory dyad in physiology and immunopathology. Therapeutic antagonism of MIF may be an effective approach for steroid-sparing therapies in patients with refractory autoimmune or inflammatory diseases.

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