Open AccessLetter to the Editor: “Glucocorticoid Resistance in Premature Adrenarche and PCOS: From Childhood to Adulthood”
Author(s) -
Robert L. Rosenfield
Publication year - 2020
Publication title -
journal of the endocrine society
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.046
H-Index - 20
ISSN - 2472-1972
DOI - 10.1210/jendso/bvaa163
Subject(s) - adrenarche , glucocorticoid , polycystic ovary , medicine , endocrinology , hormone , insulin resistance , obesity
The conclusion of Panayiotopoulos et al. that glucocorticoid resistance accounted for 57% to 67% of their premature adrenarche and polycystic ovary syndrome cases cannot be accepted from the data presented. This is because proper validation of their method for determining glucocorticoid sensitivity is not presented. Furthermore, the method seems insensitive to physiologic glucocorticoid concentrations.
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