ApoB48-Lipoproteins Are Associated with Cardiometabolic Risk in Adolescents with and without Polycystic Ovary Syndrome | Zendy

Donna F. Vine | Zendy; Lawrence J. Beilin | Zendy; Sally Burrows | Zendy; RaeChi Huang | Zendy; Martha Hickey | Zendy; Roger Hart | Zendy; Spencer D. Proctor | Zendy; Trevor A. Mori | Zendy

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ApoB48-Lipoproteins Are Associated with Cardiometabolic Risk in Adolescents with and without Polycystic Ovary Syndrome

Author(s) -

Donna F. Vine,

Lawrence J. Beilin,

Sally Burrows,

RaeChi Huang,

Martha Hickey,

Roger Hart,

Spencer D. Proctor,

Trevor A. Mori

Publication year - 2020

Publication title -

journal of the endocrine society

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.046

H-Index - 20

ISSN - 2472-1972

DOI - 10.1210/jendso/bvaa061

Subject(s) - polycystic ovary , medicine , dyslipidemia , lipoprotein(a) , endocrinology , apolipoprotein b , context (archaeology) , lipoprotein , cholesterol , obesity , insulin resistance , biology , paleontology

Fasting plasma apoB48-lipoprotein remnants but not apoB100-lipoprotein remnants were elevated in adolescent girls with increased cardiometabolic risk compared with those with lower cardiometabolic risk (13.91 ± 5.06 vs 12.09 ± 4.47 µg/mL, < .01). ApoB48-lipoprotein remnants were positively correlated with fasting plasma triglycerides (b = .43, < .0001). The prevalence of increased cardiometabolic risk factors was 2-fold higher in those diagnosed with PCOS (35.3%) than in those without PCOS (16.3%). Adolescents with PCOS have a 2-fold higher incidence of cardiometabolic risk factors than those without PCOS. Fasting apoB48-lipoprotein remnants are elevated in adolescent girls with a high prevalence of cardiometabolic risk factors.

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