Maintenance of Serum Calcium by Parathyroid Hormone-Related Peptide During Lactation in a Hypoparathyroid Patient | Zendy

Kieren J. Mather | Zendy; Constance L. Chik | Zendy; Bernard Corenblum | Zendy

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Maintenance of Serum Calcium by Parathyroid Hormone-Related Peptide During Lactation in a Hypoparathyroid Patient

Author(s) -

Kieren J. Mather,

Constance L. Chik,

Bernard Corenblum

Publication year - 1999

Publication title -

the journal of clinical endocrinology and metabolism

Language(s) - English

Resource type - Journals

eISSN - 1945-7197

pISSN - 0021-972X

DOI - 10.1210/jcem.84.2.5486

Subject(s) - lactation , parathyroid hormone , medicine , endocrinology , context (archaeology) , calcitriol , calcium , calcium metabolism , pregnancy , hypoparathyroidism , biology , paleontology , genetics

We describe the changes in calcium homeostasis seen in a hypoparathyroid woman during the third trimester and with lactation following her second pregnancy. During lactation her need for supplemental calcium and calcitriol abated, and in fact she was transiently hypercalcemic and hypophosphatemic. This change was associated with a rise of serum parathyroid hormone-related peptide (PTHrP) released systemically during lactation. This is the first documentation of the time course of serum PTHrP levels from the late third trimester throughout lactation in a hypoparathyroid woman. In this context PTHrP may have sufficient biological activity to compensate for parathyroid hormone deficiency.

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