Expression of Platelet-Derived Endothelial Cell Growth Factor (PD-ECGF) Related to Angiogenesis in Ovarian Endometriosis | Zendy

Jiro Fujimoto | Zendy; Hideki Sakaguchi | Zendy; Reiko Hirose | Zendy; Teruhiko Tamaya | Zendy

Open Access

Expression of Platelet-Derived Endothelial Cell Growth Factor (PD-ECGF) Related to Angiogenesis in Ovarian Endometriosis

Author(s) -

Jiro Fujimoto,

Hideki Sakaguchi,

Reiko Hirose,

Teruhiko Tamaya

Publication year - 1999

Publication title -

the journal of clinical endocrinology and metabolism

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.206

H-Index - 353

eISSN - 1945-7197

pISSN - 0021-972X

DOI - 10.1210/jcem.84.1.5372

Subject(s) - angiogenesis , endometriosis , growth factor , vascular endothelial growth factor , immunohistochemistry , endometrium , cancer research , medicine , vegf receptors , endocrinology , biology , receptor

Platelet-derived endothelial cell growth factor (PD-ECGF) is expressed in the lining epithelial cells of ovarian endometriomas, and in interstitial cells of the subepithelial area with angiogenesis. The expression of PD-ECGF persists in endometriotic endometrium during the menstrual cycle. This might suggest that PD-ECGF contributes to the growth of ovarian endometriomas via subepithelial angiogenesis independently of the sex steroidal milieu.

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