Early Diagnosis by Genetic Analysis of Differentiated Thyroid Cancer Metastases in Small Lymph Nodes | Zendy

Franco Arturi | Zendy; Diego Russo | Zendy; Dario Giuffrida | Zendy; A Ippolito | Zendy; Nicola Perrotti | Zendy; Riccardo Vigneri | Zendy; Sébastiano Filetti | Zendy

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Early Diagnosis by Genetic Analysis of Differentiated Thyroid Cancer Metastases in Small Lymph Nodes

Author(s) -

Franco Arturi,

Diego Russo,

Dario Giuffrida,

A Ippolito,

Nicola Perrotti,

Riccardo Vigneri,

Sébastiano Filetti

Publication year - 1997

Publication title -

the journal of clinical endocrinology and metabolism

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.206

H-Index - 353

eISSN - 1945-7197

pISSN - 0021-972X

DOI - 10.1210/jcem.82.5.4062

Subject(s) - thyroid cancer , thyroglobulin , thyroid , lymph , medicine , pathology , medical diagnosis , cancer , genetic analysis , radiology , biology , gene , genetics

We report a PCR-based technique for detecting thyroid cancer metastases in small nodes <1.5 cm diameter by the amplification of thyroid specific transcripts TSH-receptor and thyroglobulin. A 100% correspondence with the histopathological diagnosis was observed in the 41/46 nodes (89%) in which an adequate sample was obtained at fine needle aspiration. The genetic analysis resulted more sensitive and accurate than both the cytological analysis (28% inadequate samples, 17% false negative diagnoses) and the thyroglobulin measurement in the aspirates (39% false negatives). The PCR-based genetic analysis may provide a useful tool for diagnosis and follow-up of thyroid cancer.

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