Dexamethasone Increases Leptin Expression in Humans in Vivo | Zendy

S. Papaspyrou-Rao | Zendy; Stephen H. Schneider | Zendy; R. N. Petersen | Zendy; Susan K. Fried | Zendy

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Dexamethasone Increases Leptin Expression in Humans in Vivo

Author(s) -

S. Papaspyrou-Rao,

Stephen H. Schneider,

R. N. Petersen,

Susan K. Fried

Publication year - 1997

Publication title -

the journal of clinical endocrinology and metabolism

Language(s) - Uncategorized

Resource type - Journals

SCImago Journal Rank - 2.206

H-Index - 353

eISSN - 1945-7197

pISSN - 0021-972X

DOI - 10.1210/jcem.82.5.3928

Subject(s) - leptin , medicine , endocrinology , dexamethasone , adipose tissue , insulin , in vivo , messenger rna , biology , obesity , chemistry , gene , biochemistry , microbiology and biotechnology

The effect of 2 days of oral dexamethasone administration (0.75 mg twice daily) on leptin expression in healthy volunteers was tested. Dexamethasone increased the relative abundance of leptin messenger RNA in abdominal and gluteal adipose tissues by approximately 70% (P < 0.05). Dexamethasone also significantly increased serum leptin (+ 80%) and insulin concentration (+ 83%) but did not affect serum glucose. We conclude that a hypercortisolemic/hyperinsulinemic state up-regulates leptin expression at the messenger RNA level in humans.

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