Deuterium and Bromide Dilution, and Bioimpedance Spectrometry Independently Show That Growth Hormone-Deficient Adults Have an Enlarged Extracellular Water Compartment Related to Intracellular Water | Zendy

Wouter D. van Marken Lichtenbelt | Zendy; Yvonne E. M. Snel | Zendy; Robert J. Brummer | Zendy; H. P. F. Koppeschaar | Zendy

Open Access

Deuterium and Bromide Dilution, and Bioimpedance Spectrometry Independently Show That Growth Hormone-Deficient Adults Have an Enlarged Extracellular Water Compartment Related to Intracellular Water

Author(s) -

Wouter D. van Marken Lichtenbelt,

Yvonne E. M. Snel,

Robert J. Brummer,

H. P. F. Koppeschaar

Publication year - 1997

Publication title -

the journal of clinical endocrinology and metabolism

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.206

H-Index - 353

eISSN - 1945-7197

pISSN - 0021-972X

DOI - 10.1210/jcem.82.3.3833

Subject(s) - body water , extracellular fluid , fluid compartments , extracellular , intracellular , chemistry , compartment (ship) , isotope dilution , dilution , deuterium , bromide , endocrinology , medicine , body weight , mass spectrometry , chromatography , biochemistry , oceanography , physics , organic chemistry , geology , thermodynamics , quantum mechanics

GH has a strong influence on body composition. However, the effects of GH deficiency in adults on water compartments are not well understood. Therefore, extracellular water (ECW) and total body water were independently determined by deuterium and bromide dilution and by bioimpedance spectrometry in GH-deficient (GHD) adults and compared to those in controls, matched for age, sex, body weight, and height. The results show that the percent body fat was significantly (P < 0.05) higher, and total body water and intracellular water (ICW) were significantly lower in GHD adults for males, females, and both sexes combined. ECW was not significantly different between the two groups. ECW/ICW in GHD adults (0.42 ± 0.03) was significantly (P < 0.01) higher than that in controls (0.39 ± 0.02). There was a significant positive relation between the ECW/ICW ratio and the percent body fat. These results were confirmed by the bioimpedance spectrometry measurements.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research