Presence of Leptin in Colostrum and/or Breast Milk from Lactating Mothers: A Potential Role in the Regulation of Neonatal Food Intake | Zendy

Xesús Casabiell | Zendy; Verónica Piñeiro | Zendy; María Ausencia Tomé | Zendy; R. Peinó | Zendy; Carlos Diéguez | Zendy; Felipe F. Casanueva | Zendy

Open Access

Presence of Leptin in Colostrum and/or Breast Milk from Lactating Mothers: A Potential Role in the Regulation of Neonatal Food Intake

Author(s) -

Xesús Casabiell,

Verónica Piñeiro,

María Ausencia Tomé,

R. Peinó,

Carlos Diéguez,

Felipe F. Casanueva

Publication year - 1997

Publication title -

the journal of clinical endocrinology and metabolism

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.206

H-Index - 353

eISSN - 1945-7197

pISSN - 0021-972X

DOI - 10.1210/jcem.82.12.4590

Subject(s) - leptin , colostrum , breast milk , endocrinology , biology , medicine , stomach , physiology , immunology , obesity , antibody , biochemistry

In neonates both nutrients and regulatory factors are transferred from the mother to the suckling infant via milk. In the present work, it has been shown that human milk contains immunoreactive leptin which is identical to intact human leptin by criteria of charge, size, immunorecognition and SDS-PAGE mobility. In experimental animals it was demonstrated that leptin is transferred from the circulation to mothers' milk, then to the infant's stomach and afterwards to infant blood. Maternal leptin in milk may play a regulatory role in the suckling infant.

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