Metformin Improves Peripheral Insulin Sensitivity in Youth With Type 1 Diabetes | Zendy

Melanie CreeGreen | Zendy; Bryan C. Bergman | Zendy; Eda Cengiz | Zendy; Larry A. Fox | Zendy; Tamara S. Han | Zendy; Kellee M. Miller | Zendy; Brandon M. Nathan | Zendy; Laura Pyle | Zendy; Darcy E. Kahn | Zendy; Michael Tansey | Zendy; Eileen Tichy | Zendy; Eva Tsalikian | Zendy; Ingrid Libman | Zendy; Kristen J. Nadeau | Zendy

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Metformin Improves Peripheral Insulin Sensitivity in Youth With Type 1 Diabetes

Author(s) -

Melanie CreeGreen,

Bryan C. Bergman,

Eda Cengiz,

Larry A. Fox,

Tamara S. Han,

Kellee M. Miller,

Brandon M. Nathan,

Laura Pyle,

Darcy E. Kahn,

Michael Tansey,

Eileen Tichy,

Eva Tsalikian,

Ingrid Libman,

Kristen J. Nadeau

Publication year - 2019

Publication title -

the journal of clinical endocrinology and metabolism

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.206

H-Index - 353

eISSN - 1945-7197

pISSN - 0021-972X

DOI - 10.1210/jc.2019-00129

Subject(s) - metformin , type 2 diabetes , insulin sensitivity , medicine , peripheral , endocrinology , sensitivity (control systems) , diabetes mellitus , insulin , insulin resistance , engineering , electronic engineering

Type 1 diabetes in adolescence is characterized by insulin deficiency and insulin resistance (IR), both thought to increase cardiovascular disease risk. We previously demonstrated that adolescents with type 1 diabetes have adipose, hepatic, and muscle IR, and that metformin lowers daily insulin dose, suggesting improved IR. However, whether metformin improves IR in muscle, hepatic, or adipose tissues in type 1 diabetes was unknown.

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