Determining the relationship between hot flushes and LH pulses in menopausal women using mathematical modelling | Zendy

Julia Prague | Zendy; Margaritis Voliotis | Zendy; Sophie Clarke | Zendy; Alexander Comninos | Zendy; Ali Abbara | Zendy; Chan. Jayasena | Zendy; Rachel Roberts | Zendy; Lisa Yang | Zendy; Johannes D. Veldhuis | Zendy; Krasimira TsanevaAtanasova | Zendy; Craig A. McArdle | Zendy; Waljit S. Dhillo | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Determining the relationship between hot flushes and LH pulses in menopausal women using mathematical modelling

Author(s) -

Julia Prague,

Margaritis Voliotis,

Sophie Clarke,

Alexander Comninos,

Ali Abbara,

Chan. Jayasena,

Rachel Roberts,

Lisa Yang,

Johannes D. Veldhuis,

Krasimira TsanevaAtanasova,

Craig A. McArdle,

Waljit S. Dhillo

Publication year - 2019

Publication title -

the journal of clinical endocrinology and metabolism

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.206

H-Index - 353

eISSN - 1945-7197

pISSN - 0021-972X

DOI - 10.1210/jc.2018-02797

Subject(s) - menopause , medicine

Hypothalamic kisspeptin/neurokinin B/dynorphin (KNDy) neurones regulate LH pulsatility. It is widely accepted that the menopausal hot flush (HF) consistently synchronizes with the LH pulse, implicating the hypothalamic KNDy neurones in generating LH pulsatility and HF. Using a modern immunoassay and mathematical modeling, we investigated if the HF and LH pulse were consistently synchronized in menopausal women.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research