Unacylated Ghrelin Does Not Acutely Affect Substrate Metabolism or Insulin Sensitivity in Men With Type 2 Diabetes
Author(s) -
Esben Thyssen Vestergaard,
Niels Jessen,
Niels Møller,
Jens Otto Lunde Jørgensen
Publication year - 2019
Publication title -
the journal of clinical endocrinology and metabolism
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.206
H-Index - 353
eISSN - 1945-7197
pISSN - 0021-972X
DOI - 10.1210/jc.2018-02601
Subject(s) - medicine , endocrinology , lipolysis , insulin , glucose uptake , carbohydrate metabolism , glucose clamp technique , resting energy expenditure , crossover study , type 2 diabetes , ghrelin , placebo , energy expenditure , diabetes mellitus , insulin resistance , pancreatic hormone , adipose tissue , hormone , alternative medicine , pathology
Unacylated ghrelin (UAG) is suggested to improve insulin sensitivity and may have therapeutic potential. We therefore tested the effects of intravenous UAG infusion on glucose and lipid metabolism, insulin sensitivity, and energy expenditure in men with type 2 diabetes mellitus (T2DM).
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