Open AccessThe Detrimental Effects of Kynurenine, a Tryptophan Metabolite, on Human Bone Metabolism
Author(s) -
BeomJun Kim,
Mark W. Hamrick,
Hyun Ju Yoo,
Seung Hun Lee,
Su Jung Kim,
JungMin Koh,
Carlos M. Isales
Publication year - 2019
Publication title -
the journal of clinical endocrinology and metabolism
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.206
H-Index - 353
eISSN - 1945-7197
pISSN - 0021-972X
DOI - 10.1210/jc.2018-02481
Subject(s) - kynurenine , osteoprotegerin , endocrinology , medicine , bone remodeling , metabolite , bone resorption , rankl , chemistry , osteoclast , rank ligand , receptor , tryptophan , biochemistry , activator (genetics) , amino acid
Studies in aged mice support a role for kynurenine, a tryptophan metabolite, in age-induced bone loss; however, the role of kynurenine in human bone metabolism is not well understood.
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