A Polygenic Risk Score of Lipolysis-Increasing Alleles Determines Visceral Fat Mass and Proinsulin Conversion | Zendy

Daniela Kempe-Teufel | Zendy; Fausto Machicao | Zendy; Jürgen Machann | Zendy; Anja Böhm | Zendy; Fritz Schick | Zendy; Andreas Fritsche | Zendy; Norbert Stefan | Zendy; Martin Hrabě de Angelis | Zendy; HansUlrich Häring | Zendy; Harald Staiger | Zendy

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A Polygenic Risk Score of Lipolysis-Increasing Alleles Determines Visceral Fat Mass and Proinsulin Conversion

Author(s) -

Daniela Kempe-Teufel,

Fausto Machicao,

Jürgen Machann,

Anja Böhm,

Fritz Schick,

Andreas Fritsche,

Norbert Stefan,

Martin Hrabě de Angelis,

HansUlrich Häring,

Harald Staiger

Publication year - 2019

Publication title -

the journal of clinical endocrinology and metabolism

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.206

H-Index - 353

eISSN - 1945-7197

pISSN - 0021-972X

DOI - 10.1210/jc.2018-02042

Subject(s) - lipolysis , medicine , endocrinology , proinsulin , adipose tissue , single nucleotide polymorphism , insulin resistance , insulin , biology , type 2 diabetes , diabetes mellitus , genetics , gene , genotype

Primary dysregulation of adipose tissue lipolysis caused by genetic variation and independent of insulin resistance could explain unhealthy body fat distribution and its metabolic consequences.

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