Causal Link Between Vitamin D and Total Testosterone in Men: A Mendelian Randomization Analysis | Zendy

Chi Chen | Zendy; Hualing Zhai | Zendy; Jing Cheng | Zendy; Pan Weng | Zendy; Yi Chen | Zendy; Qin Li | Zendy; Chiyu Wang | Zendy; Fangzhen Xia | Zendy; Ningjian Wang | Zendy; Yingli Lu | Zendy

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Causal Link Between Vitamin D and Total Testosterone in Men: A Mendelian Randomization Analysis

Author(s) -

Chi Chen,

Hualing Zhai,

Jing Cheng,

Pan Weng,

Yi Chen,

Qin Li,

Chiyu Wang,

Fangzhen Xia,

Ningjian Wang,

Yingli Lu

Publication year - 2019

Publication title -

the journal of clinical endocrinology and metabolism

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.206

H-Index - 353

eISSN - 1945-7197

pISSN - 0021-972X

DOI - 10.1210/jc.2018-01874

Subject(s) - mendelian randomization , vitamin d and neurology , medicine , endocrinology , testosterone (patch) , vitamin d deficiency , biology , genetics , genetic variants , genotype , gene

Low circulating vitamin D levels have been associated with lower total testosterone levels. These epidemiological associations, if true, would have public health importance because vitamin D deficiency is common and correctable. We tested whether genetically lowered vitamin D levels were associated with lower total testosterone (T), using Mendelian randomization (MR) methodology.

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