Endocrine Disruption of Androgenic Activity by Perfluoroalkyl Substances: Clinical and Experimental Evidence | Zendy

Andrea Di Nisio | Zendy; Iva Šabović | Zendy; Umberto Valente | Zendy; Simone Tescari | Zendy; Maria Santa Rocca | Zendy; Diego Guidolin | Zendy; Stefano Dall’Acqua | Zendy; Laura Acquasaliente | Zendy; Nicola Pozzi | Zendy; Mario Plebani | Zendy; Andrea Garolla | Zendy; Carlo Foresta | Zendy

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Endocrine Disruption of Androgenic Activity by Perfluoroalkyl Substances: Clinical and Experimental Evidence

Author(s) -

Andrea Di Nisio,

Iva Šabović,

Umberto Valente,

Simone Tescari,

Maria Santa Rocca,

Diego Guidolin,

Stefano Dall’Acqua,

Laura Acquasaliente,

Nicola Pozzi,

Mario Plebani,

Andrea Garolla,

Carlo Foresta

Publication year - 2018

Publication title -

the journal of clinical endocrinology and metabolism

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.206

H-Index - 353

eISSN - 1945-7197

pISSN - 0021-972X

DOI - 10.1210/jc.2018-01855

Subject(s) - endocrine system , testosterone (patch) , hormone , semen quality , physiology , male infertility , infertility , biology , perfluorooctanoic acid , medicine , endocrinology , semen , andrology , pregnancy , genetics , biochemistry

Considerable attention has been paid to perfluoroalkyl compounds (PFCs) because of their worldwide presence in humans, wildlife, and environment. A wide variety of toxicological effects is well supported in animals, including testicular toxicity and male infertility. For these reasons, the understanding of epidemiological associations and of the molecular mechanisms involved in the endocrine-disrupting properties of PFCs on human reproductive health is a major concern.

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