The Gly385(388)Arg Polymorphism of the FGFR4 Receptor Regulates Hepatic Lipogenesis Under Healthy Diet | Zendy

Stefan Lutz | Zendy; Anita M. Hennige | Zendy; Andreas Peter | Zendy; Markéta Kovářová | Zendy; Charisis Totsikas | Zendy; Jürgen Machann | Zendy; Stefan Kröber | Zendy; Bianca Sperl | Zendy; Erwin Schleicher | Zendy; Fritz Schick | Zendy; Martin Heni | Zendy; Axel Ullrich | Zendy; HansUlrich Häring | Zendy; Norbert Stefan | Zendy

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The Gly385(388)Arg Polymorphism of the FGFR4 Receptor Regulates Hepatic Lipogenesis Under Healthy Diet

Author(s) -

Stefan Lutz,

Anita M. Hennige,

Andreas Peter,

Markéta Kovářová,

Charisis Totsikas,

Jürgen Machann,

Stefan Kröber,

Bianca Sperl,

Erwin Schleicher,

Fritz Schick,

Martin Heni,

Axel Ullrich,

HansUlrich Häring,

Norbert Stefan

Publication year - 2018

Publication title -

the journal of clinical endocrinology and metabolism

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.206

H-Index - 353

eISSN - 1945-7197

pISSN - 0021-972X

DOI - 10.1210/jc.2018-01573

Subject(s) - medicine , endocrinology , lipogenesis , lipid metabolism , fgf21 , biology , insulin , fatty liver , triglyceride , carbohydrate metabolism , insulin resistance , cholesterol , receptor , fibroblast growth factor , disease

The effect of a lifestyle intervention to reduce liver fat content in nonalcoholic fatty liver disease in humans is influenced by genetics. We hypothesized that the amino acid exchange in human Gly388Arg (mouse homolog: Gly385Arg) in fibroblast growth factor receptor 4 (FGFR4), which regulates bile acid, lipid, and glucose metabolism, could determine hepatic lipid accumulation and insulin sensitivity. Mechanisms of this substitution were studied in mice under normal chow and high-fat diets.

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