Association of Plasma Vitamin D Metabolites With Incident Type 2 Diabetes: EPIC-InterAct Case-Cohort Study
Author(s) -
JuSheng Zheng,
Fumiaki Imamura,
Stephen J. Sharp,
Yvonne T. van der Schouw,
Ivonne Sluijs,
Thomas E. Gundersen,
Eva Ardanáz,
Heiner Boeing,
Catalina Bonet,
Jesús Humberto Gómez Gómez,
Courtney Dow,
Guy Fagherazzi,
Paul W. Franks,
Mazda Jenab,
Tilman Kühn,
Rudolf Kaaks,
Timothy J. Key,
KayTee Khaw,
Cristina Lasheras,
Olatz Mokoroa,
Francesca Romana Mancini,
Peter M. Nilsson,
Kim Overvad,
Salvatore Panico,
Domenico Palli,
Olov Rolandsson,
Sabina Sieri,
Elena SalamancaFernández,
Carlotta Sacerdote,
Annemieke M. W. Spijkerman,
Magdalena Stępień,
Anne Tjønneland,
Rosario Tumino,
Adam S. Butterworth,
Elio Ríboli,
John Danesh,
Claudia Langenberg,
Nita G. Forouhi,
Nicholas J. Wareham
Publication year - 2018
Publication title -
the journal of clinical endocrinology and metabolism
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.206
H-Index - 353
eISSN - 1945-7197
pISSN - 0021-972X
DOI - 10.1210/jc.2018-01522
Subject(s) - european prospective investigation into cancer and nutrition , vitamin d and neurology , hazard ratio , type 2 diabetes , prospective cohort study , metabolite , medicine , proportional hazards model , endocrinology , confidence interval , diabetes mellitus , chemistry , gastroenterology
Existing evidence for the prospective association of vitamin D status with type 2 diabetes (T2D) is focused almost exclusively on circulating total 25-hydroxyvitamin D [25(OH)D] without distinction between its subtypes: nonepimeric and epimeric 25(OH)D3 stereoisomers, and 25(OH)D2, the minor component of 25(OH)D. We aimed to investigate the prospective associations of circulating levels of the sum and each of these three metabolites with incident T2D.
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