Immune Profiling of Thyroid Carcinomas Suggests the Existence of Two Major Phenotypes: an ATC-like and a PDTC-like | Zendy

Riccardo Giannini | Zendy; Sonia Moretti | Zendy; Clara Ugolini | Zendy; Elisabetta Macerola | Zendy; Elisa Menicali | Zendy; Nicole Nucci | Zendy; Silvia Morelli | Zendy; Renato Colella | Zendy; Martina Mandarano | Zendy; Angelo Sidoni | Zendy; Matteo Panfili | Zendy; Fulvio Basolo | Zendy; Efisio Puxeddu | Zendy

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Immune Profiling of Thyroid Carcinomas Suggests the Existence of Two Major Phenotypes: an ATC-like and a PDTC-like

Author(s) -

Riccardo Giannini,

Sonia Moretti,

Clara Ugolini,

Elisabetta Macerola,

Elisa Menicali,

Nicole Nucci,

Silvia Morelli,

Renato Colella,

Martina Mandarano,

Angelo Sidoni,

Matteo Panfili,

Fulvio Basolo,

Efisio Puxeddu

Publication year - 2019

Publication title -

the journal of clinical endocrinology and metabolism

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.206

H-Index - 353

eISSN - 1945-7197

pISSN - 0021-972X

DOI - 10.1210/jc.2018-01167

Subject(s) - immune system , thyroid cancer , cancer research , thyroid , gene expression profiling , cd8 , thyroid carcinoma , downregulation and upregulation , tigit , tumor microenvironment , biology , medicine , immunology , gene expression , gene , biochemistry

The understanding of the mechanisms underlying thyroid cancer immune escape can lead to the identification of new molecular targets and/or efficacy biomarkers. For this purpose, we performed immune expression profiling in thyroid cancers to obtain a comprehensive view on immune mechanisms activated during cancer progression.

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