Open AccessTargeted Molecular Characterization of Aldosterone-Producing Adenomas in White Americans
Author(s) -
Kazutaka Nanba,
Kei Omata,
Tobias Else,
Peter C.C. Beck,
Aya T Nanba,
Adina F. Turcu,
Barbra S. Miller,
Thomas J. Giordano,
Scott A. Tomlins,
William E. Rainey
Publication year - 2018
Publication title -
the journal of clinical endocrinology and metabolism
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.206
H-Index - 353
eISSN - 1945-7197
pISSN - 0021-972X
DOI - 10.1210/jc.2018-01004
Subject(s) - aldosterone , white (mutation) , adenoma , medicine , endocrinology , biology , genetics , gene
Somatic mutations have been identified in more than half of aldosterone-producing adenomas (APAs) through mutation hotspot sequencing. The underlying pathogenesis of inappropriate aldosterone synthesis in the remaining population is still unknown.
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