Mediator Kinase Disruption in MED12-Mutant Uterine Fibroids From Hispanic Women of South Texas | Zendy

Min Ju Park | Zendy; Hailian Shen | Zendy; Nam Hee Kim | Zendy; Fangjian Gao | Zendy; Courtney Failor | Zendy; Jennifer F. Knudtson | Zendy; Jessica McLaughlin | Zendy; Sunil K. Halder | Zendy; Tuomas Heikkinen | Zendy; Pia Vahteristo | Zendy; Ayman AlHendy | Zendy; Robert S. Schenken | Zendy; Thomas G. Boyer | Zendy

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Mediator Kinase Disruption in MED12-Mutant Uterine Fibroids From Hispanic Women of South Texas

Author(s) -

Min Ju Park,

Hailian Shen,

Nam Hee Kim,

Fangjian Gao,

Courtney Failor,

Jennifer F. Knudtson,

Jessica McLaughlin,

Sunil K. Halder,

Tuomas Heikkinen,

Pia Vahteristo,

Ayman AlHendy,

Robert S. Schenken,

Thomas G. Boyer

Publication year - 2018

Publication title -

the journal of clinical endocrinology and metabolism

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.206

H-Index - 353

eISSN - 1945-7197

pISSN - 0021-972X

DOI - 10.1210/jc.2018-00863

Subject(s) - mediator , genetics , cyclin dependent kinase 8 , biology , microbiology and biotechnology , gene , notch signaling pathway

Mutations in the gene encoding Mediator complex subunit MED12 are dominant drivers of uterine fibroids (UFs) in women of diverse racial and ethnic origins. Previously, we showed that UF-linked mutations in MED12 disrupt its ability to activate cyclin C-CDK8/19 in Mediator. However, validation of Mediator kinase disruption in the clinically relevant setting of MED12-mutant UFs is currently lacking.

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