Clinical and Molecular Characteristics May Alter Treatment Strategies of Thyroid Malignancies in DICER1 Syndrome | Zendy

Karin van der Tuin | Zendy; Leanne de Kock | Zendy; Eveline J. Kamping | Zendy; Sabine E Hannema | Zendy; Marie-Jose M Pouwels | Zendy; Marek Niedziela | Zendy; Tom van Wezel | Zendy; Frederik J. Hes | Zendy; Marjolijn C.J. Jongmans | Zendy; William D. Foulkes | Zendy; Hans Morreau | Zendy

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Clinical and Molecular Characteristics May Alter Treatment Strategies of Thyroid Malignancies in DICER1 Syndrome

Author(s) -

Karin van der Tuin,

Leanne de Kock,

Eveline J. Kamping,

Sabine E Hannema,

Marie-Jose M Pouwels,

Marek Niedziela,

Tom van Wezel,

Frederik J. Hes,

Marjolijn C.J. Jongmans,

William D. Foulkes,

Hans Morreau

Publication year - 2018

Publication title -

the journal of clinical endocrinology and metabolism

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.206

H-Index - 353

eISSN - 1945-7197

pISSN - 0021-972X

DOI - 10.1210/jc.2018-00774

Subject(s) - medicine , thyroid carcinoma , thyroid cancer , thyroidectomy , germline mutation , thyroid , context (archaeology) , thyroid nodules , pathology , retrospective cohort study , oncology , mutation , gene , biology , genetics , paleontology

DICER1 syndrome is a rare autosomal-dominantly inherited disorder that predisposes to a variety of cancerous and noncancerous tumors of mostly pediatric and adolescent onset, including differentiated thyroid carcinoma (DTC). DTC has been hypothesized to arise secondarily to the increased prevalence of thyroid hyperplastic nodules in syndromic patients.

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