11-ketotestosterone is the dominant circulating bioactive androgen during normal and premature adrenarche | Zendy

Juilee Rege | Zendy; Adina F. Turcu | Zendy; Joséphine Z. Kasa-Vubu | Zendy; Antônio Marcondes Lerário | Zendy; Gabriela C Auchus | Zendy; Richard J. Auchus | Zendy; Joshua M. Smith | Zendy; Perrin C. White | Zendy; William E. Rainey | Zendy

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11-ketotestosterone is the dominant circulating bioactive androgen during normal and premature adrenarche

Author(s) -

Juilee Rege,

Adina F. Turcu,

Joséphine Z. Kasa-Vubu,

Antônio Marcondes Lerário,

Gabriela C Auchus,

Richard J. Auchus,

Joshua M. Smith,

Perrin C. White,

William E. Rainey

Publication year - 2018

Publication title -

the journal of clinical endocrinology and metabolism

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.206

H-Index - 353

eISSN - 1945-7197

pISSN - 0021-972X

DOI - 10.1210/jc.2018-00736

Subject(s) - adrenarche , endocrinology , medicine , zona reticularis , androgen , dehydroepiandrosterone , dehydroepiandrosterone sulfate , testosterone (patch) , pubic hair , chemistry , androstenediol , hormone , receptor , zona glomerulosa , angiotensin ii

Adrenarche refers to the rise of dehydroepiandrosterone sulfate (DHEA-S) associated with the development of a functional adrenal zona reticularis. Clinical features of adrenarche include onset of body odor, axillary hair, and pubic hair, which reflect increased androgen action. An early rise in adrenal androgens, or premature adrenarche (PremA), is a risk factor for adverse metabolic profiles in adolescence and adulthood. The bioactive androgens associated with adrenarche and PremA remain poorly understood. The adrenal gland is a potential source of testosterone (T) and the 11-oxygenated derivatives 11β-hydroxytestosterone (11OHT) and 11-ketotestosterone (11KT).

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