Open AccessMacimorelin as a Diagnostic Test for Adult GH Deficiency
Author(s) -
José M. Garcia,
Beverly M. K. Biller,
Márta Korbonits,
Vera Popović,
Anton Luger,
Christian J. Strasburger,
Philippe Chanson,
Milica MedicStojanoska,
Jochen Schopohl,
Anna Zakrzewska,
Sandra Pekić,
Marek Bolanowski,
Ronald S. Swerdloff,
Christina Wang,
Thomas Blevins,
Marco Marcelli,
Nicola Ammer,
Richard Sachse,
Kevin C.J. Yuen
Publication year - 2018
Publication title -
the journal of clinical endocrinology and metabolism
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.206
H-Index - 353
eISSN - 1945-7197
pISSN - 0021-972X
DOI - 10.1210/jc.2018-00665
Subject(s) - medicine , insulin tolerance test , cutoff , hypoglycemia , crossover study , endocrinology , adverse effect , gastroenterology , hypopituitarism , insulin , placebo , insulin sensitivity , insulin resistance , pathology , physics , alternative medicine , quantum mechanics
The diagnosis of adult GH deficiency (AGHD) is challenging and often requires confirmation with a GH stimulation test (GHST). The insulin tolerance test (ITT) is considered the reference standard GHST but is labor intensive, can cause severe hypoglycemia, and is contraindicated for certain patients. Macimorelin, an orally active GH secretagogue, could be used to diagnose AGHD by measuring stimulated GH levels after an oral dose.
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