Imbalanced Expression of IGF2 and PCSK4 Is Associated With Overproduction of Big IGF2 in SFT With NICTH: A Pilot Study | Zendy

Shintaro Kawai | Zendy; Hiroyuki Ariyasu | Zendy; Shinsuke Uraki | Zendy; Ken Takeshima | Zendy; Shuhei Morita | Zendy; Hidefumi Inaba | Zendy; Hiroshi Iwakura | Zendy; Asako Doi | Zendy; Takuya Ohashi | Zendy; Mitsumasa Kawago | Zendy; Naoki Matsuoka | Zendy; Shintaro Okamura | Zendy; Satoru Tsujii | Zendy; Takashi Akamizu | Zendy

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Imbalanced Expression of IGF2 and PCSK4 Is Associated With Overproduction of Big IGF2 in SFT With NICTH: A Pilot Study

Author(s) -

Shintaro Kawai,

Hiroyuki Ariyasu,

Shinsuke Uraki,

Ken Takeshima,

Shuhei Morita,

Hidefumi Inaba,

Hiroshi Iwakura,

Asako Doi,

Takuya Ohashi,

Mitsumasa Kawago,

Naoki Matsuoka,

Shintaro Okamura,

Satoru Tsujii,

Takashi Akamizu

Publication year - 2018

Publication title -

the journal of clinical endocrinology and metabolism

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.206

H-Index - 353

eISSN - 1945-7197

pISSN - 0021-972X

DOI - 10.1210/jc.2018-00593

Subject(s) - overproduction , expression (computer science) , mathematics , computer science , biology , genetics , programming language , gene

Nonislet cell tumor hypoglycemia (NICTH) is a rare but serious paraneoplastic syndrome associated with large tumors. The high molecular weight IGF2, known as "big" IGF2, is produced by culprit tumors and leads to severe hypoglycemia. The detailed mechanism of its production in NICTH, however, remains unclear.

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