Open AccessHydrocortisone Affects Fatigue and Physical Functioning Through Metabolism of Tryptophan: A Randomized Controlled Trial
Author(s) -
Freek J. H. Sorgdrager,
Jorien Werumeus Buning,
Elske H. Bos,
André P. van Beek,
Ido P. Kema
Publication year - 2018
Publication title -
the journal of clinical endocrinology and metabolism
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.206
H-Index - 353
eISSN - 1945-7197
pISSN - 0021-972X
DOI - 10.1210/jc.2018-00582
Subject(s) - kynurenine , tryptophan , medicine , endocrinology , hydrocortisone , glucocorticoid , metabolism , randomized controlled trial , chemistry , amino acid , biochemistry
Hydrocortisone (HC) treatment influences health-related quality of life (HRQOL) in secondary adrenal insufficiency (AI). Glucocorticoids regulate tryptophan metabolism through the kynurenine pathway, which modulates mood and energy homeostasis.
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