Interferon-α Triggers Autoimmune Thyroid Diseases via Lysosomal-Dependent Degradation of Thyroglobulin | Zendy

Larissa C. Faustino | Zendy; Angela Lombardi | Zendy; Julio MadrigalMatute | Zendy; Randall P. Owen | Zendy; Steven K. Libutti | Zendy; Yaron Tomer | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Interferon-α Triggers Autoimmune Thyroid Diseases via Lysosomal-Dependent Degradation of Thyroglobulin

Author(s) -

Larissa C. Faustino,

Angela Lombardi,

Julio MadrigalMatute,

Randall P. Owen,

Steven K. Libutti,

Yaron Tomer

Publication year - 2018

Publication title -

the journal of clinical endocrinology and metabolism

Language(s) - Uncategorized

Resource type - Journals

SCImago Journal Rank - 2.206

H-Index - 353

eISSN - 1945-7197

pISSN - 0021-972X

DOI - 10.1210/jc.2018-00541

Subject(s) - thyroglobulin , endocrinology , autophagy , medicine , xbp1 , thyroid , thyroiditis , protein degradation , downregulation and upregulation , endoplasmic reticulum , interferon , biology , chemistry , immunology , microbiology and biotechnology , gene , biochemistry , rna , apoptosis , rna splicing

Autoimmune thyroid diseases (AITDs) arise from complex interactions among genetic, epigenetic, and environmental factors. Thyroglobulin (TG) is a major susceptibility gene for both Graves disease and Hashimoto thyroiditis. Interferon-α (IFNα), a cytokine secreted during viral infections, has emerged as a key trigger of AITD. We have shown that IFNα upregulates TG transcription; however, how the upregulation of TG transcription by IFNα triggers AITD is still unknown.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research