Open AccessGlucocorticoid Receptor Mutations and Hypersensitivity to Endogenous and Exogenous Glucocorticoids
Author(s) -
Richard J. Santen,
Christine M. Jewell,
Wei Yue,
Daniel F. Heitjan,
Hershel Raff,
Kevin S. Katen,
John A. Cidlowski
Publication year - 2018
Publication title -
the journal of clinical endocrinology and metabolism
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.206
H-Index - 353
eISSN - 1945-7197
pISSN - 0021-972X
DOI - 10.1210/jc.2018-00352
Subject(s) - glucocorticoid receptor , glucocorticoid , adrenal insufficiency , biology , endocrinology , medicine
The glucocorticoid receptor (GR) consists of two alternatively spliced isoforms: GRα, which activates gene transcription, and GRβ, a dominant-negative receptor. Theoretically, inactivating variants of GRβ could result in glucocorticoid hypersensitivity.
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