Randomized, Placebo-Controlled Trial to Evaluate Effects of Eplerenone on Metabolic and Inflammatory Indices in HIV | Zendy

Suman Srinivasa | Zendy; Kathleen V. Fitch | Zendy; Kimberly Wong | Zendy; Timothy K O’Malley | Zendy; Patrick Maehler | Zendy; Karen L. Branch | Zendy; Sara E. Looby | Zendy; Tricia H. Burdo | Zendy; Edgar L. Martínez-Salazar | Zendy; Martin Torriani | Zendy; Shan Lyons | Zendy; Julian J. Weiss | Zendy; Meghan N. Feldpausch | Zendy; Takara L. Stanley | Zendy; Gail K. Adler | Zendy; Steven Grinspoon | Zendy

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Randomized, Placebo-Controlled Trial to Evaluate Effects of Eplerenone on Metabolic and Inflammatory Indices in HIV

Author(s) -

Suman Srinivasa,

Kathleen V. Fitch,

Kimberly Wong,

Timothy K O’Malley,

Patrick Maehler,

Karen L. Branch,

Sara E. Looby,

Tricia H. Burdo,

Edgar L. Martínez-Salazar,

Martin Torriani,

Shan Lyons,

Julian J. Weiss,

Meghan N. Feldpausch,

Takara L. Stanley,

Gail K. Adler,

Steven Grinspoon

Publication year - 2018

Publication title -

the journal of clinical endocrinology and metabolism

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.206

H-Index - 353

eISSN - 1945-7197

pISSN - 0021-972X

DOI - 10.1210/jc.2018-00330

Subject(s) - eplerenone , medicine , endocrinology , aldosterone , insulin resistance , mineralocorticoid receptor , placebo , spironolactone , insulin , pathology , alternative medicine

HIV-infected individuals demonstrate increased renin-angiotensin-aldosterone system activation in association with visceral adiposity, insulin resistance, and inflammation. A physiologically based treatment approach targeting mineralocorticoid receptor (MR) blockade may improve metabolic and inflammatory indices in HIV.

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