Melanocortin 4 Receptor Pathway Dysfunction in Obesity: Patient Stratification Aimed at MC4R Agonist Treatment | Zendy

Kristin L. Ayers | Zendy; Benjamin S. Glicksberg | Zendy; Alastair S. Garfield | Zendy; Simonne Longerich | Zendy; Joseph White | Zendy; Yang Pengwei | Zendy; Lei Du | Zendy; Thomas W. Chittenden | Zendy; Jeffery R. Gulcher | Zendy; Sophie Roy | Zendy; Fred T. Fiedorek | Zendy; Keith Gottesdiener | Zendy; Sarah S. Cohen | Zendy; Kari E. North | Zendy; Eric E. Schadt | Zendy; Shuyu Dan Li | Zendy; Rong Chen | Zendy; Lex H.T. Van der Ploeg | Zendy

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Melanocortin 4 Receptor Pathway Dysfunction in Obesity: Patient Stratification Aimed at MC4R Agonist Treatment

Author(s) -

Kristin L. Ayers,

Benjamin S. Glicksberg,

Alastair S. Garfield,

Simonne Longerich,

Joseph White,

Yang Pengwei,

Lei Du,

Thomas W. Chittenden,

Jeffery R. Gulcher,

Sophie Roy,

Fred T. Fiedorek,

Keith Gottesdiener,

Sarah S. Cohen,

Kari E. North,

Eric E. Schadt,

Shuyu Dan Li,

Rong Chen,

Lex H.T. Van der Ploeg

Publication year - 2018

Publication title -

the journal of clinical endocrinology and metabolism

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.206

H-Index - 353

eISSN - 1945-7197

pISSN - 0021-972X

DOI - 10.1210/jc.2018-00258

Subject(s) - melanocortin 4 receptor , melanocortin , endocrinology , biology , medicine , allele , melanocortin receptor , genetics , leptin , leptin receptor , gene , obesity , hormone

The hypothalamic melanocortin 4 receptor (MC4R) pathway serves a critical role in regulating body weight. Loss of function (LoF) mutations in the MC4R pathway, including mutations in the pro-opiomelanocortin (POMC), prohormone convertase 1 (PCSK1), leptin receptor (LEPR), or MC4R genes, have been shown to cause early-onset severe obesity.

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