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DICER1 Mutations Are Frequent in Adolescent-Onset Papillary Thyroid Carcinoma
Author(s) -
Jonathan D. Wasserman,
Nelly Sabbaghian,
Somayyeh Fahiminiya,
Rose Chami,
Özgür Mete,
Meryl Acker,
Mona K. Wu,
Adam Shlien,
Leanne de Kock,
William D. Foulkes
Publication year - 2018
Publication title -
the journal of clinical endocrinology and metabolism
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.206
H-Index - 353
eISSN - 1945-7197
pISSN - 0021-972X
DOI - 10.1210/jc.2017-02698
Subject(s) - thyroid carcinoma , germline mutation , medicine , thyroid cancer , thyroid nodules , thyroidectomy , thyroid , malignancy , cancer research , exon , genotyping , carcinoma , pathology , mutation , biology , gene , genotype , genetics
Papillary thyroid carcinoma (PTC) is a common malignancy in adolescence and is molecularly and clinically distinct from adult PTC. Mutations in the DICER1 gene are associated with thyroid abnormalities, including multinodular goiter and differentiated thyroid carcinoma.

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